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News
Evaluating frailty in aging mice: current methods and challenges
21+ hour, 47+ min ago (759+ words) Frailty, the state of heightened vulnerability that emerges as biological reserves dwindle with age, has become one of the most consequential concepts in modern geriatric medicine....
Multi-omics signatures of type 2 diabetes subgroups predict insulin
3+ day, 12+ hour ago (728+ words) Type 2 diabetes has long been treated in the clinic as a single disease defined by elevated blood glucose, yet a growing body of research has argued that it is better understood as a collection of distinct disorders that converge on…...
Multiomics approach reverses age-related disease susceptibility in oysters
3+ day, 22+ hour ago (780+ words) In the world of infectious disease, aging is almost universally a liability. As animals grow older, their immune systems typically falter, their cellular repair mechanisms decline, and their susceptibility to pathogens climbs. Humans, mice, fish, and insects all obey this…...
Worldwide study shows limits to how long humans can live
4+ day, 10+ hour ago (772+ words) There are few questions in science that grip the public imagination quite like the limits of human longevity, and a new study published in the journal Biogerontology now adds a substantial piece of evidence to one of the most contentious…...
Fertility benefits may explain why harmful disease genes persist in humans
1+ week, 1+ day ago (32+ words) Bioengineer.org Subject of Research: Biology Article Title: Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans...
New Multi-City Cohort Study Examines Elderly Health Across China
1+ week, 1+ day ago (142+ words) China has unveiled the extraordinary scale of one of the world’s largest prospective studies of aging, with the publication of a cohort profile describing the Multi-city Elderly Health Examination Cohort Study, or MEHECS, in the European Journal of Epidemiology. Since…...
Magnesium Emerges as Key Regulator of Mitochondria, Metabolism, and Aging
1+ week, 1+ day ago (76+ words) Magnesium has spent most of its scientific life backstage — the unglamorous electrolyte that keeps cellular housekeeping running while genes, proteins, and metabolites take the spotlight. A new review published in the journal Aging Cell argues that this quiet reputation is…...
High-definition brain stimulation fails to boost motor learning in older
1+ week, 1+ day ago (98+ words) Brain Stimulation Fails Its Most Rigorous Aging Test: Major Pre-Registered Trial Finds No Motor-Learning Boost from tDCS in Older Adults The answer to both was no. All four groups showed robust motor sequence learning: reaction times shortened dramatically as practice…...
EVERGREEN Study Evaluates Everolimus After Progression in Advanced
1+ week, 2+ day ago (593+ words) Everolimus Offers Only a Modest Extra Brake on Advanced Breast Cancer After CDK4/6 Resistance For patients with estrogen receptor-positive, HER2-negative advanced breast cancer, the moment a tumor progresses on a CDK4/6 inhibitor can feel like a therapeutic cliff....
Aging Essential 8: Bridging Geroscience and the Public
1+ week, 3+ day ago (85+ words) The race to measure biological aging has produced a problem almost as quickly as it has produced new technology: people are receiving numbers they cannot reliably interpret. DNA methylation tests promise to reveal whether someone is biologically older or younger…...