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Perivascular space, brain functional connectivity and sleep: a healthy aging population study | npj Biological Timing and Sleep
4+ hour ago (1684+ words) npj Biological Timing and Sleep volume3, Articlenumber: 21 (2026) Cite this article Our next objective was to investigate whether sleep was associated with PVS-related FCs. These PVS-related FCs and PSQI sleep components did not show any significant correlation. (Table 4). To further investigate the…...
How long can humans live? We simply don't know
2+ day, 4+ hour ago (887+ words) Claims about the upper limits to human lifespan are characterized by hype, deficient data and shoddy science, says longevity researcher Saul Newman. Claims about the upper limits to human lifespan are characterized by hype, deficient data and shoddy science, says…...
Healthspan research focuses on living healthier, not just longer
6+ mon, 3+ week ago (646+ words) Ageing is as certain as the sunrise, but science is beginning to challenge what that certainty really means. At the Icahn School of Medicine at Mount Sinai (ISMMS) in New York City, researchers are reframing ageing as a process that…...
Crosstalk between lipid metabolism and epigenetics in cellular senescence and age-related diseases - npj Aging
2+ week, 4+ hour ago (84+ words) npj Aging (2026) Cite this article We thank the team members for their valuable and constructive comments. Also, we thank all those involved in writing and revising this manuscript. This research was funded by Science and Technology Development Projects of Jilin…...
Peroxisomes orchestrate metabolic flexibility and longevity via an interorganelle cascade - Nature Aging
2+ week, 4+ hour ago (1751+ words) Nature Aging volume6, pages 9871006 (2026) Cite this article a, Representative micrograph of fat stores using NR staining of fixed WT, D1 or D8, fed and fasted animals showing induction of metabolic inflexibility with age (from n=3 biological replicates, n=1518 animals per condition, two-tailed Student's…...
From whole-body to organ-specific biological age clocks - Nature Aging
2+ week, 4+ hour ago (1615+ words) Nature Aging volume6, pages 961969 (2026) Cite this article Ferrucci, L. , Barzilai, N. , Belsky, D. W. & Gladyshev, V. N. How to measure biological aging in humans. Nat. Med. 31, 1057 (2025). L'pez-Ot'n, C. , Blasco, M. A. , Partridge, L. , Serrano, M. & Kroemer, G. The hallmarks of aging. Cell 153, 11941217 (2013). Horvath, S. DNA methylation age of human tissues and cell types. Genome…...
Too little or too much sleep is linked to faster ageing throughout the body
2+ week, 4+ hour ago (102+ words) A multimodal analysis reveals a ‘U-shaped’ association between sleep duration and biological ageing across various organ systems, with too much or not enough sleep being linked with accelerated organ ageing. The study also shows that biological ageing differentially mediates the…...
Daily briefing: Around seven hours of sleep slows biological ageing
2+ week, 6+ day ago (74+ words) Between six and eight hours of sleep each day seems to be a ‘sweet spot’ for preventing disease. Plus, unexpected interbreeding between Denisovans and Homo erectus, and how the look of antibiotics could be driving antimicrobial resistance. Between six and…...
Glutamine-driven reductive TCA cycle metabolism supports aged muscle stem cell function via de novo lipogenesis - Nature Aging
2+ week, 6+ day ago (1545+ words) Nature Aging (2026) Cite this article All source data will be provided as a Source Data file. Other data will be available from the corresponding author upon reasonable request. Martinez, B. P. et al. Frequency of sarcopenia and associated factors among hospitalized elderly…...
Whole-blood NAD+ levels do not reflect healthy ageing - Nature Metabolism
2+ week, 6+ day ago (245+ words) Nature Metabolism (2026) Cite this article Levels of NAD+ have been widely proposed to decline with age in humans, but whether this holds true in whole blood remains unclear. Using a robust approach across multiple cohorts, we show that whole-blood NAD…...