4+ day, 4+ hour ago   (156+ words) Mapped 5' start position Mapped start position and UMI sequence Distinguishes independent molecules at the same position Appropriate for WGS germline variant calling Yes, with added overhead Appropriate for deep targeted panel sequencing No; removes genuine fragments Yes, via consensus calling…...

4+ day, 10+ hour ago   (596+ words) More than two decades after scientists first sequenced the entire human genome — all 3 billion “letters,” or base pairs, of DNA code — the meaning of much of this code remains a mystery. Researchers at UC Berkeley have created a new genomic language…...

5+ day, 5+ hour ago   (200+ words) Technology Networks Connect these carbon triangles to an amine, a functional group with a nitrogen at its center, and you get aminocyclopropanes. They are of particular interest in pharmaceutical research because they can be used to replace another substructure commonly…...

5+ day, 10+ hour ago   (580+ words) As an embryo develops from a small cluster of stem cells, those once “blank slate” cells begin to take on more specialized roles like brain, liver, or muscle cells, and organize themselves into three-dimensional structures such as tissues and organs....

1+ week, 9+ hour ago   (239+ words) The human body and its gut microbiome produce thousands of small molecules that shape how the body functions—influencing immunity, metabolism, and more. Identifying what those molecules actually are has been one of the biomedical sciences’ most persistent bottlenecks. More…...

1+ week, 4+ day ago   (457+ words) Evolution has created an astonishing amount of diversity, shaping much of our understanding of biology. But this diversity, which took billions of years to emerge, barely scratches the surface of what could have existed given the trillions of possible DNA…...

1+ week, 5+ day ago   (251+ words) Spatial transcriptomics is a powerful tool to create a detailed map of not just how genes are expressed in a piece of tissue, but also where genetic activity takes place in different cells and locations within the tissue. This is…...

1+ week, 5+ day ago   (187+ words) These phylogenetic trees are built using algorithms, which suggest the most likely tree based on the available genetic data. Various parameters can be estimated, such as the rate at which a pathogen spreads, the duration of infection, its geographical origin,…...

3+ week, 3+ day ago   (454+ words) If you want to describe a particular color, you could look to the Pantone color wheel to find its exact hue, saturation and brightness, and how it compares to other colors. But nothing like that has existed for complex odors....

3+ week, 4+ day ago   (250+ words) Now, researchers from Hokkaido University have developed a new, fast, and accurate way to predict these metal-binding sites. Their method, called PRIME (Probe-based Identification of Metal-binding sites), is described in Nature Communications and uses a deep-learning approach to solve this…...