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Evaluating frailty in aging mice: current methods and challenges
1+ week, 9+ hour ago (759+ words) Frailty, the state of heightened vulnerability that emerges as biological reserves dwindle with age, has become one of the most consequential concepts in modern geriatric medicine....
Loss of cGAS disrupts H3K9me3 organization and derepresses LINE1 to cause inflammaging - Nature Aging
2+ week, 5+ day ago (162+ words) Nature Aging (2026) Cite this article Simon, M. et al. LINE1 derepression in aged wild-type and SIRT6 deficient mice drives inflammation. Cell Metab. 29, 871–885 (2019). This paper reports that LINE1 cDNA accumulation drives inflammation via cGAS–STING signaling. Miller, K. et al. Cytoplasmic DNA: sources, sensing, and…...
Your Gut Microbiome May Reveal How Fast You're Biologically Aging
2+ week, 6+ day ago (352+ words) Your gut is keeping track of more than last night's dinner. The bacteria living there are constantly responding to your diet, lifestyle, medications, sleep habits, and even stress. Over time, that microbial community becomes a reflection of the life you've…...
Noncircadian BMAL1–YAP signaling amplifies chronic inflammation in aging
2+ week, 6+ day ago (679+ words) Aging Skin’s Molecular Switch: Noncircadian BMAL1–YAP Cooperation Amplifies Chronic Inflammation Aging skin is often described as a visible record of time, but its decline is also the result of a persistent molecular disturbance. As tissues grow older, they become less…...
How gut bacteria linked to muscle strength could help fight ageing
3+ week, 3+ day ago (839+ words) Muscle strength helps us to maintain independence later in life The trillions of microbes living in the human gut are increasingly recognised as important partners in human health. Scientists have linked the gut microbiome to several aspects of health, from…...
Blue Zones: 5 key foods eaten in Sardinia for longevity to add to your diet
3+ week, 3+ day ago (818+ words) We're in the midst of a monumental wellness shift. Where health was once almost exclusively related to body image, we're now looking beyond the here and now at how our bodies will function in the latter parts of our lives…...
How Old Fat Cells Trigger Inflammation and Raise Risks
3+ week, 3+ day ago (336+ words) Using cohort studies and a mouse model, researchers have found that the circulating factor ANGPTL8, which is produced by senescent fat cells, is related to age-related diseases and mortality in mice and people. [2] Ou, M. Y., Zhang, H., Tan, P. C., Zhou, S. B., & Li, Q. F. (2022). Adipose tissue aging:…...
Infection, Immunity, and Redox Metabolism in Aging: Comparative and Evolutionary Perspectives
1+ mon, 2+ day ago (258+ words) The aging process is characterized by a progressive decline in physiological function, culminating in increased susceptibility to infections, altered immune... You will be redirected to our submission process. About this Research Topic Manuscript Submission Deadline 28 February 2027 This Research Topic is…...